Will The MCU Ever Have A Big Hero Meet Up?

So, Renner(who plays Hawkeye) said Gaurdians won't be meeting Avengers in Infinity War like most expect. Which means it'll most likely just be, the Earths heroes teamed up against him.

Now if this is true my question is. Will the Earths Mightiest Heroes ever meet up with Gaurdians and other heroes like Defenders? Will they ever all team up and have a big blow out with a villain?