What would be the Event that would spark the downfall of Marvel Studios?

I know it seems impossible and nor do I ever want it to happen but it would be just fun to speculate the crazy wacky scenarios.

If there's already another thread on this please link it.

I'll start:

1. Avi Arad getting insanely rich and buying Marvel Studios from Disney.
2. A female Thor movie is green-lit and Paul Feig is tapped to direct.